Fact checked by Nick Blackmer Tirzepatide and semaglutide, the ingredients in popular weight loss drugs, can both cause side effects, such as nausea, vomiting, and diarrhea.One is not safer than the other—tolerance to the medications largely depends on the patient.

In the first direct comparison study involving individuals with obesity, tirzepatide demonstrated approximately 50% greater weight loss compared to semaglutide. This landmark finding

Those who take tirzepatide, the drug sold as Zepbound and Mounjaro, could lose more weight than those who take semaglutide, known as Ozempic and Wegovy, according to new research.